The Drug-Induced Respiratory Disease Website

Asparaginase

l-asparaginase

Bronchospasm - Wheezing - Asthma

Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.