The Drug-Induced Respiratory Disease Website

Abciximab

Main risk is bland alveolar hemorrhage. DAH may mimic pulmonary edema on imaging. Risk increases with left ventricular failure and concomitant anticoagulation. Diagnosis is by BAL. Prompt drug withdrawal is indicated

XII - Pericardial involvement

XII.c

Hemopericardium - Bloody pericardial effusion

XVI - Hemorrhage - Bleeding - Hematoma(s)

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f

Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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