Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

Crizotinib

In some countries it is believed that ILD develops in up to 2-4% of patients who receive the drug. Prior ILD may be a risk factor (PMID 25413260). Separating drug-induced ILD from disease progression, radiation pneumonitis, hemorrhage or an infection can be arduous. PMID 29174221

I - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e

Bradycardia

VII - Cardiotoxicity

VII.a

‘Cardiotoxicity’

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

Acute lung injury - ARDS

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (ILD)