The Drug-Induced Respiratory Disease Website

Ipilimumab

An inhibitor of CTL A-4 lymphocyte domain used to treat melanoma (PMID 23714523). Reviews on management of AE at PMID 23772560, 24278787. Incidence of ILD higher if ipilumab and nivolumab are given concomitantly (PMID 25891304)

XXIX - Small airway involvement

XXIX.i

Exacerbation or deterioration of preexisting COPD

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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