The Drug-Induced Respiratory Disease Website

Nitrites - Nitrates (‘Poppers’)

Raw, in drinking/well water or deposited on food. Foodborne nitrites/nitrates should also be considered (PMID 4693932, 30293223)

Methemoglobinemia

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.