The Drug-Induced Respiratory Disease Website

Alendronate

Alendronate may cause severe laryngotracheal injury following pill aspiration into the aiway, representing topical chemical injury rather than true drug-induced disease.

XXXII - Esophageal pathology

XXXII.e

Esophageal toxicity

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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