Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

XXII.e

Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

Presentation may range from restrictive lung dysfunction to acute respiratory failure with an increased PaCO2 and respiratory acidosis and blunted ventilatory reponse to hypoxia and/or hypercarbia. Aspiration, brain damage and death can occur (See PMID 25536092). See also under IXi, IXIe, IXa, IXj, IXs.

Publications

Chen SJ, Yeh CM, Chao TF, Liu CJ, Wang KL, Chen TJ, Chou P, Wang FD

The Use of Benzodiazepine Receptor Agonists and Risk of Respiratory Failure in Patients with Chronic Obstructive Pulmonary Disease: A Nationwide Population-Based Case-Control Study.

Sleep 2015 Jul 01;38;1045-50 — 2015 Jul 01 — 1045-50

Alonso T, García E, Segrelles G, Zamora E

Respiratory acidosis secondary to drug therapy.

Archivos de bronconeumologia 2015 Apr;51;204-5 — 2015 Apr — 204-5

Lee SC, Klein-Schwartz W, Doyon S, Welsh C

Comparison of toxicity associated with nonmedical use of benzodiazepines with buprenorphine or methadone.

Drug and alcohol dependence 2014 May 01;138;118-23 — 2014 May 01 — 118-23

Guo AY, Ma JD, Best BM, Atayee RS

Urine specimen detection of concurrent nonprescribed medicinal and illicit drug use in patients prescribed buprenorphine.

Journal of analytical toxicology 2013 Nov-Dec;37;636-41 — 2013 Nov-Dec — 636-41

Kuhlman JJ, McCaulley R, Valouch TJ, Behonick GS

Fentanyl use, misuse, and abuse: a summary of 23 postmortem cases.

Journal of analytical toxicology 2003 Oct;27;499-504 — 2003 Oct — 499-504

Gueye PN, Lofaso F, Borron SW, Mellerio F, Vicaut E, Harf A, Baud FJ

Mechanism of respiratory insufficiency in pure or mixed drug-induced coma involving benzodiazepines.

Journal of toxicology. Clinical toxicology 2002;40;35-47 — 2002 — 35-47