The Drug-Induced Respiratory Disease Website

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XI. Pulmonary vasculopathies

XI.f Worsening of preexisting PHTn

XII. Pericardial involvement

XII.g Pleural/pericardial effusion, ANA positive (DI lupus)

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.h Pleural thickening - Fibrothorax

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.e Relapsing or migrating pneumonitis/pneumonia (see also Id)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.h Pulmonary fibrosis (may improve but partly following drug discontinuation)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.c Severe or catastrophic bronchospasm or asthma attack (can be fatal)

XXIX. Small airway involvement

XXIX.h Exacerbation or deterioration of preexisting asthma

XXIX. Small airway involvement

XXIX.i Exacerbation or deterioration of preexisting COPD

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.b Lupus - Lupus syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.d Subclinical ANA positivity

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.l Refractoriness to epineprine in case of anaphylaxis

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

II. Myocardial dysfunction - Heart failure

II.e Acute respiratory or cardiopulmonary failure

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XIII. Thrombosis - Embolism

XIII.o Systemic arterial thrombosis

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.h Coagulopathy

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXI. Mediastinal involvement/injury

XXI.c Pneumomediastinum

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.w Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.k Multiple organ dysfunction/failure (MODS/MOF)

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

XXXVIII. Miscellaneous - Varia

XXXVIII.r Hyperemesis

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.e Acute respiratory or cardiopulmonary failure

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.j Asystole

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

III. Myocardial ischemia - Coronary artery disease

III.e Coronary artery dissection

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XIV. Pleural involvement

XIV.f Pneumothorax

XIV. Pleural involvement

XIV.l Pneumothorax, bilateral

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXI. Mediastinal involvement/injury

XXI.c Pneumomediastinum

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.d Acute eosinophilic pneumonia (AEP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.y Exogenous lipoid pneumonia (subacute, acute)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ad Pulmonary alveolar proteinosis (PAP)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.ae Pneumoconiosis (silicosis, talcosis...)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.af Hypersensitivity pneumonitis pattern

XXIX. Small airway involvement

XXIX.d Cough (lone)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVIII. Miscellaneous - Varia

XXXVIII.e Sniffing death - Death from inhalation of compound

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.i Torsades de pointe

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.n Respiratory arrest - Apnea

II. Myocardial dysfunction - Heart failure

II.b Right ventricular dysfunction/failure

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XIII. Thrombosis - Embolism

XIII.k Foreign body pulmonary vasculopathy (Excipient lung disease)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXII. Acute respiratory/cardiorespiratory failure

XXII.f Rigid chest syndrome - Chest wall rigidity - Stiff/wooden chest

XXXV. Disordered breathing during sleep

XXXV.b Disordered breathing pattern - Cheynes-Stokes respiration

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

XXXVIII. Miscellaneous - Varia

XXXVIII.h Hypoxemia, low oxygen saturation (may occur in isolation)