Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

XXII.e

Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

Presentation may range from restrictive lung dysfunction to acute respiratory failure with an increased PaCO2 and respiratory acidosis and blunted ventilatory reponse to hypoxia and/or hypercarbia. Aspiration, brain damage and death can occur (See PMID 25536092). See also under IXi, IXIe, IXa, IXj, IXs.

Publications

Dasgupta K, Nielson S

Coma and Respiratory Failure in a 2-Year-Old Child After Accidental Overdose of Baclofen.

South Dakota medicine : the journal of the South Dakota State Medical Association 2020 Mar;73;106-110 — 2020 Mar — 106-110

Kamal RM, Qurishi R, De Jong CA

Baclofen and ?-hydroxybutyrate (GHB), a dangerous combination.

Journal of addiction medicine 2015 Jan-Feb;9;75-7 — 2015 Jan-Feb — 75-7

Kiel LB, Hoegberg LC, Jansen T, Petersen JA, Dalhoff KP

A nationwide register-based survey of baclofen toxicity.

Basic & clinical pharmacology & toxicology 2015 May;116;452-6 — 2015 May — 452-6

Stroud J, Scattoloni J, Blasingim M, Nafiu OO

Intrathecal baclofen toxicity: an unusual cause of paediatric postoperative coma and respiratory depression.

European journal of anaesthesiology 2014 Jun;31;334-6 — 2014 Jun — 334-6

Choo YM, Kim GB, Choi JY, Park JH, Park JH, Yang CW, Kim YS, Bang BK

Severe respiratory depression by low-dose baclofen in the treatment of chronic hiccups in a patient undergoing CAPD.

Nephron 2000 Dec;86;546-7 — 2000 Dec — 546-7