The Drug-Induced Respiratory Disease Website

Clopidogrel

Hemothorax - Serosanguineous pleural effusion

Boulé S, Marquié C, Vanesson-Bricout C, Kouakam C, Brigadeau F, Guédon-Moreau L, Acheré C, Goéminne-Boulé C, Lacroix D, Klug D, Kacet S

Clopidogrel increases bleeding complications in patients undergoing heart rhythm device procedures.

Pacing and clinical electrophysiology : PACE 2012 May;35;605-11 — 2012 May — 605-11

Borderías Clau L, Garrapiz López J, Caballero G

[Pulmonary haemorrhage and haemothorax after massive ingestion of clopidogrel as a suicide attempt].

Archivos de bronconeumologia 2009 Nov;45;570-1 — 2009 Nov — 570-1

Haro Estarriol M, Alvarez Castillo LA, Baldó Padró X, Palou Rispau A, Rubio Garay M, Rubio Goday M

[Bilateral hemothorax secondary to combined antiplatelet therapy with clopidogrel and acetylsalicylic acid].

Archivos de bronconeumologia 2006 Jun;42;307-9 — 2006 Jun — 307-9

Shennib H, Endo M, Benhameid O

A feasibility study of the safety and efficacy of a combined clopidogrel and aspirin regimen following off-pump coronary artery bypass grafting.

The heart surgery forum 2003;6;288-91 — 2003 — 288-91

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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