The Drug-Induced Respiratory Disease Website

Infliximab

Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

(Fr: fibrose pulmonaire accélérée). Often refractory to costicosteroid therapy. Can be fatal. See also under Iy

Horai Y, Miyamura T, Shimada K, Takahama S, Minami R, Yamamoto M, Suematsu E

Eternacept for the treatment of patients with rheumatoid arthritis and concurrent interstitial lung disease.

Journal of clinical pharmacy and therapeutics 2012 Feb;37;117-21 — 2012 Feb — 117-21

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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