Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

Infliximab

Hypesrentitivity infusion reactions are common (PMID 12818276). For those ILD cases exposed to methotrexate concomitantly, drug causality assessment in regards to infliximab is difficult.

V - Myocarditis

V.a

Myocarditis (can be fulminate/fulminant)

XII - Pericardial involvement

XII.a

Pericarditis
XII.g

Pleural/pericardial effusion, ANA positive (DI lupus)

XIII - Thrombosis - Embolism

XIII.a

Pulmonary embolism - Venous thrombosis/thrombo-embolism
XIII.n

Right ventricular thrombus/thrombosis

XIV - Pleural involvement

XIV.a

Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XVI - Hemorrhage - Bleeding - Hematoma(s)

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

XXII - Acute respiratory/cardiorespiratory failure

XXII.b

Acute lung injury - ARDS

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.d

Acute eosinophilic pneumonia (AEP)
XXIV.h

Pulmonary fibrosis (may improve but partly following drug discontinuation)
XXIV.i

Progression, acceleration or exacerbation of preexisting ILD/fibrosis
XXIV.j

Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)
XXIV.o

Rapidly progressive ILD/pulmonary fibrosis (Hamman-Rich syndrome)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma

XXX - Imaging features

XXX.l

Imaging: Ground-glass opacities / GGO shadowing

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.a

Autoimmunity - An autoimmune condition (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)
XXXVI.b

Lupus - Lupus syndrome
XXXVI.u

Pulmonary vasculitis or capillaritis

XXXVIII - Miscellaneous - Varia

XXXVIII.c

Antiphospholipid antibodies w/wo the APL syndrome