The Drug-Induced Respiratory Disease Website

Infliximab

Imaging: Ground-glass opacities / GGO shadowing

Can be localized, disseminated or diffuse

Sen S, Peltz C, Jordan K, Boes TJ

Infliximab-induced nonspecific interstitial pneumonia.

The American journal of the medical sciences 2012 Jul;344;75-8 — 2012 Jul — 75-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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