The Drug-Induced Respiratory Disease Website

Hydralazine

Vocal cord dysfunction, adduction, closure

Vocal cords or folds (PMID 29037819). May result from drug-induced paralysis. See also under 'Laryngospasm' (VIIIe) with which this condition may overlap. See also under VIIIt.

Publications

Hari CK, Raza SA, Clayton MI

Hydralazine-induced lupus and vocal fold paralysis.

The Journal of laryngology and otology 1998 Sep;112;875-7 — 1998 Sep — 875-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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