The Drug-Induced Respiratory Disease Website

Hemothorax - Serosanguineous pleural effusion

Publications

Vun SV, Lance DG

Life-threatening pleural hemorrhage following intrapleural enzyme therapy and successful treatment with fibrin-thrombin sealant pleurodesis: a case report.

Journal of medical case reports 2015 Dec 18;9;287 — 2015 Dec 18 — 287

Varnholt V, Ringe H, Nietsch L, Gaedicke G

Hemothorax under thrombolytic therapy with recombinant tissue: plasminogen activator (rt-PA) in a 16-year-old girl.

European journal of pediatrics 1999 Dec;158 Suppl 3;S140-2 — 1999 Dec — S140-2

Cafri C, Gilutz H, Ilia R, Abu-ful A, Battler A

Unusual bleeding complications of thrombolytic therapy after cardiopulmonary resuscitation. Three case reports.

Angiology 1997 Oct;48;925-8 — 1997 Oct — 925-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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