The Drug-Induced Respiratory Disease Website

Hematoma of/around central airway wall potentially causing UAO

UAO: upper airway obstruction. Hematoma may localize in the mouth floor, tongue, retropharyngeal space, epiglottis, airway wall or localize in the mediastinum around the airway potentially causing UAO

Publications

Sutter R, Bruder E, Weissenburg M, Balestra GM

Thyroid hemorrhage causing airway obstruction after intravenous thrombolysis for acute ischemic stroke.

Neurocritical care 2013 Dec;19;381-4 — 2013 Dec — 381-4

Bal M, Atar Y, Salturk Z, Ate? AH, Ya?c? S, Co?kun Bal G

Lingual Haematoma due to Tenecteplase in a Patient with Acute Myocardial Infarction.

Case reports in otolaryngology 2013;2013;239796 — 2013 — 239796

Vijayan S, Chase A

Images in clinical medicine. Lingual hematoma after thrombolytic therapy.

The New England journal of medicine 2011 Feb 17;364;e13 — 2011 Feb 17 — e13

Yigla M, Sprecher E, Azzam Z, Guralnik L, Kapeliovich M, Krivoy N

Diffuse alveolar hemorrhage following thrombolytic therapy for acute myocardial infarction.

Respiration; international review of thoracic diseases 2000;67;445-8 — 2000 — 445-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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