The Drug-Induced Respiratory Disease Website

Adalimumab

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

A cause-and-effect relationship is uncertain (PMID 20374322)

Ozkan H, Cetinkaya AS, Yildiz T, Bozat T

A Rare Side Effect due to TNF-Alpha Blocking Agent: Acute Pleuropericarditis with Adalimumab.

Case reports in rheumatology 2013;2013;985914 — 2013 — 985914

Annapureddy N, Agarwal SK, Ammakkanavar N, Kanakadandi V, Sabharwal MS, Sanjani HP, Simoes P, Nadkarni GN

Tumor necrosis factor inhibitor-induced serositis.

American journal of therapeutics 2014 Sep-Oct;21;e166-8 — 2014 Sep-Oct — e166-8

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.