Philippe Camus, M.D.
Dijon, France
XII - Pericardial involvement
Last update 17/06/2026
See also under ANA-positive (lupus) effusions Vd. Large effusions may cause cardiac tamponade or respiratory failure. Occasional cases due to drug-induced hypothroidism (PMIiD 26319226)
II. Myocardial dysfunction - Heart failure
II.c Heart failure (biventricular, congestive)
XII. Pericardial involvement
XII.g Pleural/pericardial effusion, ANA positive (DI lupus)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.g Alveolar hemorrhage, diffuse (ANCA-positive/-related)
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.h Pulmonary fibrosis (may improve but partly following drug discontinuation)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)
XXVI. Neuromuscular dysfunction
XXVI.a Phrenic nerve injury - Hemi- or bilateral diaphragmatic paralysis
XXIX. Small airway involvement
XXIX.a Bronchospasm - Wheezing - Asthma
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.a Autoimmunity - An autoimmune condition (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.b Lupus - Lupus syndrome
XXXVIII. Miscellaneous - Varia
XXXVIII.c Antiphospholipid antibodies w/wo the APL syndrome
XXXVIII. Miscellaneous - Varia
XXXVIII.q Myopathy-Myositis-Polymyositis
X. Pulmonary edema
X.b Pulmonary edema, noncardiogenic (NCPE)
X. Pulmonary edema
X.i Pulmonary edema/ARDS of the ATRA syndrome
X. Pulmonary edema
X.j The differentiation- or ATRA syndrome
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIII. Thrombosis - Embolism
XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)
V. Myocarditis
V.a Myocarditis (can be fulminate/fulminant)
V. Myocarditis
V.b Eosinophilic myocarditis
VI. Cardiomyopathy
VI.a Cardiomyopathy (acute, subacute, chronic)
VII. Cardiotoxicity
VII.a ‘Cardiotoxicity’
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIII. Thrombosis - Embolism
XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXVIII. Large airway involvement
XXVIII.a Angioedema (may cause UAO, asphyxia and death)
XXIX. Small airway involvement
XXIX.a Bronchospasm - Wheezing - Asthma
XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)
XXXIII.b Path: Lymphocytic myocarditis
XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)
XXXIII.c Path: Eosinophilic myocarditis
X. Pulmonary edema
X.d Fluid retention
XI. Pulmonary vasculopathies
XI.a Pulmonary arterial hypertension
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XII. Pericardial involvement
XII.g Pleural/pericardial effusion, ANA positive (DI lupus)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV. Pleural involvement
XIV.h Pleural thickening - Fibrothorax
XIV. Pleural involvement
XIV.n Chylothorax
XV. Chest pain
XV.a Chest pain (acute or subacute), lone or prominent
XV. Chest pain
XV.e Pleuritis (can cause chest pain)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.i Progression, acceleration or exacerbation of preexisting ILD/fibrosis
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.ad Pulmonary alveolar proteinosis (PAP)
XXX. Imaging features
XXX.w Imaging: Interlobular septal thickening
XXX. Imaging features
XXX.x Imaging: Pleural effusion
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.b Lupus - Lupus syndrome
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XII. Pericardial involvement
XII.e Constrictive pericarditis - Pericardial thickening
XII. Pericardial involvement
XII.g Pleural/pericardial effusion, ANA positive (DI lupus)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XV. Chest pain
XV.e Pleuritis (can cause chest pain)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.g Alveolar hemorrhage, diffuse (ANCA-positive/-related)
XX. Vasculitis
XX.c Vascultis (pulmonary, extrathoracic or systemic) - ANCA status unknown or negative
XX. Vasculitis
XX.d Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)
XXVIII. Large airway involvement
XXVIII.a Angioedema (may cause UAO, asphyxia and death)
XXVIII. Large airway involvement
XXVIII.d Vocal cord dysfunction, adduction, closure
XXIX. Small airway involvement
XXIX.a Bronchospasm - Wheezing - Asthma
XXIX. Small airway involvement
XXIX.b Occupational asthma
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.a Autoimmunity - An autoimmune condition (+ANA, +anti-ds-DNA, +ANCAs, other auto-Abs)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.b Lupus - Lupus syndrome
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.s Dual MPO-/PR3-ANCA systemic disease/vasculitis or pseudovasculitis
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.t Pneumorenal syndrome (w/wo ANCAs)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.u Pulmonary vasculitis or capillaritis
XXXVIII. Miscellaneous - Varia
XXXVIII.a Upper airway obstruction other than angioedema or hematoma
III. Myocardial ischemia - Coronary artery disease
III.a Coronary artery disease (acute) - Myocardial ischemia/infarction
XI. Pulmonary vasculopathies
XI.a Pulmonary arterial hypertension
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.i Hemoptysis
XVIII. Aortic involvement
XVIII.c Arterial (aorta, limb) vasoconstriction and/or ischemia, acute
XX. Vasculitis
XX.d Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive
XXVIII. Large airway involvement
XXVIII.p Nasal, palatal and/or pharyngeal pathology
XXXI. Eye catchers
XXXI.h Midline destructive lesions
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.s Dual MPO-/PR3-ANCA systemic disease/vasculitis or pseudovasculitis
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.t Pneumorenal syndrome (w/wo ANCAs)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.u Pulmonary vasculitis or capillaritis
XXXVIII. Miscellaneous - Varia
XXXVIII.d Death following exposure or poisoning
XXXVIII. Miscellaneous - Varia
XXXVIII.q Myopathy-Myositis-Polymyositis
XXXVIII. Miscellaneous - Varia
XXXVIII.y Neutropenia, agranulocytosis (w/wo infection/sepsis)
II. Myocardial dysfunction - Heart failure
II.a Left ventricular dysfunction/failure
II. Myocardial dysfunction - Heart failure
II.d Cardiovascular collapse - Cardiogenic shock - Hypotension
III. Myocardial ischemia - Coronary artery disease
III.a Coronary artery disease (acute) - Myocardial ischemia/infarction
V. Myocarditis
V.a Myocarditis (can be fulminate/fulminant)
V. Myocarditis
V.b Eosinophilic myocarditis
V. Myocarditis
V.f Myopericarditis
X. Pulmonary edema
X.a Pulmonary edema, cardiogenic
XII. Pericardial involvement
XII.a Pericarditis
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV. Pleural involvement
XIV.d Eosinophilic pleural effusion
XV. Chest pain
XV.a Chest pain (acute or subacute), lone or prominent
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.d Acute eosinophilic pneumonia (AEP)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.p An area or areas of consolidation
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.s ILD with a granulomatous component
XXVIII. Large airway involvement
XXVIII.m Bronchiectasis
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.b Lupus - Lupus syndrome
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
II. Myocardial dysfunction - Heart failure
II.d Cardiovascular collapse - Cardiogenic shock - Hypotension
III. Myocardial ischemia - Coronary artery disease
III.a Coronary artery disease (acute) - Myocardial ischemia/infarction
IV. Heart block (bundle branch-, AV-block)
IV.a Heart block (bundle branch- or AV-)
V. Myocarditis
V.a Myocarditis (can be fulminate/fulminant)
VII. Cardiotoxicity
VII.a ‘Cardiotoxicity’
X. Pulmonary edema
X.a Pulmonary edema, cardiogenic
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XXII. Acute respiratory/cardiorespiratory failure
XXII.b Acute lung injury - ARDS
XXVIII. Large airway involvement
XXVIII.k Rhinosinusitis
XXIX. Small airway involvement
XXIX.a Bronchospasm - Wheezing - Asthma
XXIX. Small airway involvement
XXIX.e Obliterative bronchiolitis (an imaging and/or pathological pattern consistent with)
XXIX. Small airway involvement
XXIX.i Exacerbation or deterioration of preexisting COPD
XXIX. Small airway involvement
XXIX.l Bronchiolitis (a clinical-imaging pattern suggestive of)
XXXII. Esophageal pathology
XXXII.e Esophageal toxicity
XXXII. Esophageal pathology
XXXII.j Esophageal necrosis
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.q Tumor lysis syndrome (TLS)
II. Myocardial dysfunction - Heart failure
II.c Heart failure (biventricular, congestive)
IV. Heart block (bundle branch-, AV-block)
IV.a Heart block (bundle branch- or AV-)
V. Myocarditis
V.a Myocarditis (can be fulminate/fulminant)
XI. Pulmonary vasculopathies
XI.a Pulmonary arterial hypertension
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIII. Thrombosis - Embolism
XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXVIII. Large airway involvement
XXVIII.i Tongue involvement (edema, glossitis, hematoma)
XXIX. Small airway involvement
XXIX.a Bronchospasm - Wheezing - Asthma
XXIX. Small airway involvement
XXIX.i Exacerbation or deterioration of preexisting COPD
XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)
XXXIII.a Path: Myocarditis
XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)
XXXIII.f Path: Myocardial vasculitis
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.h Myasthenia gravis - Myasthenic-like syndrome
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.v Temporal arteritis (Horton’s)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.ad Polymyalgia rheumatica
XII. Pericardial involvement
XII.b Pericardial effusion (w/wo tamponade)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIX. Small airway involvement
XXIX.o Airway hyperresponsiveness
I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)
I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
XII. Pericardial involvement
XII.g Pleural/pericardial effusion, ANA positive (DI lupus)
XII. Pericardial involvement
XII.n Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
XIV. Pleural involvement
XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
XIV. Pleural involvement
XIV.d Eosinophilic pleural effusion
XVI. Hemorrhage - Bleeding - Hematoma(s)
XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.a Pneumonitis (ILD)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis
XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXXVI. Autoimmune syndromes - Systemic reactions or conditions
XXXVI.m DRES syndrome - DRESS-like reaction - Drug hypersensitivity syndrome
