The Drug-Induced Respiratory Disease Website

Hydralazine

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

See also under ANA-positive (lupus) effusions Vd. Large effusions may cause cardiac tamponade or respiratory failure. Occasional cases due to drug-induced hypothroidism (PMIiD 26319226)

Publications

DUSTAN HP, TAYLOR RD, CORCORAN AC

Rheumatic and febrile syndrome during prolonged hydralazine treatment.

Journal of the American Medical Association 1954 Jan 02;154;23-9 — 1954 Jan 02 — 23-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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