The Drug-Induced Respiratory Disease Website

Leflunomide

Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)

See also under ANA-positive (lupus) effusions Vd. Large effusions may cause cardiac tamponade or respiratory failure. Occasional cases due to drug-induced hypothroidism (PMIiD 26319226)

Publications

Vandenbos F, Figueredo M, Tarhini A, Ribière J

[Pleuro-pericarditis developed under a leflunomide therapy].

Revue de pneumologie clinique 2015 Feb;71;57-9 — 2015 Feb — 57-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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