The Drug-Induced Respiratory Disease Website

Mesalazine-Mesalamine-5-aminosalicylic acid-5ASA-5-aminosalicylate

Eosinophilic pleural effusion

(Pleural eosinophilie >10%). Peripheral eosinophilia, eosinophilic pleuritis, eosinophilic pneumonia and/or BAL eosinophilia can be present as associated features. See PMID 10424528, 12806236

Publications

Al-Abcha A, Raziq F, Kherallah S, Alratroot A

Mesalamine-induced eosinophilic pleural effusion.

BMJ case reports 2020 Apr 16;13; — 2020 Apr 16

Trisolini R, Dore R, Biagi F, Luinetti O, Pochetti P, Carrabino N, Luisetti M

Eosinophilic pleural effusion due to mesalamine. Report of a rare occurrence.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2000 Oct;17;288-91 — 2000 Oct — 288-91

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

LATEST CHANGELOG

No activity has been recorded yet.

View full changelog