The Drug-Induced Respiratory Disease Website

Angiotensin converting enzyme inhibitors (ACEI)

Eosinophilic pleural effusion

(Pleural eosinophilie >10%). Peripheral eosinophilia, eosinophilic pleuritis, eosinophilic pneumonia and/or BAL eosinophilia can be present as associated features. See PMID 10424528, 12806236

Publications

Yoshida H, Hasegawa R, Hayashi H, Irie Y

Imidapril-induced eosinophilic pleurisy. Case report and review of the literature.

Respiration; international review of thoracic diseases 2005 Jul-Aug;72;423-6 — 2005 Jul-Aug — 423-6

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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