The Drug-Induced Respiratory Disease Website

Tenecteplase

Hematoma of/around central airway wall potentially causing UAO

UAO: upper airway obstruction. Hematoma may localize in the mouth floor, tongue, retropharyngeal space, epiglottis, airway wall or localize in the mediastinum around the airway potentially causing UAO

Publications

Bal M, Atar Y, Salturk Z, Ate? AH, Ya?c? S, Co?kun Bal G

Lingual Haematoma due to Tenecteplase in a Patient with Acute Myocardial Infarction.

Case reports in otolaryngology 2013;2013;239796 — 2013 — 239796

Kirkham L, Homewood J, Brook P

Case of the month: A case of airway obstruction following tenecteplase administration.

Emergency medicine journal : EMJ 2006 Oct;23;815-6 — 2006 Oct — 815-6

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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