The Drug-Induced Respiratory Disease Website

Pulmonary hypertension of the newborn (Persistent PHT)

Review at PMID 25765845

Grigoriadis S, Vonderporten EH, Mamisashvili L, Tomlinson G, Dennis CL, Koren G, Steiner M, Mousmanis P, Cheung A, Ross LE

Prenatal exposure to antidepressants and persistent pulmonary hypertension of the newborn: systematic review and meta-analysis.

BMJ (Clinical research ed.) 2014 Jan 14;348;f6932 — 2014 Jan 14 — f6932

Puthiyachirakkal M, Mhanna MJ

Pathophysiology, management, and outcome of persistent pulmonary hypertension of the newborn: a clinical review.

Frontiers in pediatrics 2013 Sep 02;1;23 — 2013 Sep 02 — 23

Alwan S, Friedman JM

Safety of selective serotonin reuptake inhibitors in pregnancy.

CNS drugs 2009;23;493-509 — 2009 — 493-509

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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