The Drug-Induced Respiratory Disease Website

Selective serotonin reuptake inhibitors (SSRI) - Serotonergic drugs

The main issue is persistent pulmonary hypertension in the newborn. Evidence for a link of SRIs and PHT in adults is limited

‘Cardiotoxicity’

Pulmonary arterial hypertension

Pulmonary hypertension of the newborn (Persistent PHT)

Worsening of preexisting PHTn

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Acute eosinophilic pneumonia (AEP)

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

No activity has been recorded yet.