The Drug-Induced Respiratory Disease Website

Bendamustine

Dyspnea, unexplained otherwise

Usually , subacute/chronic, lone, with no definite evidence for underlying involvement, disease or explanation. A workup for drug-induced asthma, the 'locked lung', pulmonary embolism, and hemoglobinpathies is required. Ticagrelor is a significant etiologic contributor to this pattern

Publications

Lammers PE, Shyr Y, Li CI, Hutchison AS, Sandler A, Carbone DP, Johnson DH, Keedy VL, Horn L

Phase II study of bendamustine in relapsed chemotherapy sensitive or resistant small-cell lung cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2014 Apr;9;559-62 — 2014 Apr — 559-62

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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