The Drug-Induced Respiratory Disease Website

Amiodarone

Acute pulmonary hypertension

Amiodarone via the i.v. route

Denault AY, Beaulieu Y, Couture P, Haddad F, Shi Y, Pagé P, Levesque S, Tardif JC, Lambert J

Acute intraoperative effect of intravenous amiodarone on right ventricular function in patients undergoing valvular surgery.

European heart journal. Acute cardiovascular care 2015 Aug;4;316-25 — 2015 Aug — 316-25

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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