The Drug-Induced Respiratory Disease Website

Nitrofurantoin

Pleuritic chest pain

Can be transfixiating. Exaggerated at end-inspiration. See also under pleural involvement (Vi, Vo) and XIb

Williams EM, Triller DM

Recurrent acute nitrofurantoin-induced pulmonary toxicity.

Pharmacotherapy 2006 May;26;713-8 — 2006 May — 713-8

Linnebur SA, Parnes BL

Pulmonary and hepatic toxicity due to nitrofurantoin and fluconazole treatment.

The Annals of pharmacotherapy 2004 Apr;38;612-6 — 2004 Apr — 612-6

Boggess KA, Benedetti TJ, Raghu G

Nitrofurantoin-induced pulmonary toxicity during pregnancy: a report of a case and review of the literature.

Obstetrical & gynecological survey 1996 Jun;51;367-70 — 1996 Jun — 367-70

Jick SS, Jick H, Walker AM, Hunter JR

Hospitalizations for pulmonary reactions following nitrofurantoin use.

Chest 1989 Sep;96;512-5 — 1989 Sep — 512-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.