The Drug-Induced Respiratory Disease Website

Capecitabine

Lymphadenopathy (intrathoracic)

Can be hilar and/or mediastinal. Typically detected on imaging. Pathology may reveal granulomatous or reactive changes

Kang SM, Baek JY, Hwangbo B, Kim HY, Lee GK, Lee HS

A case of capecitabine-induced sarcoidosis.

Tuberculosis and respiratory diseases 2012 Mar;72;318-22 — 2012 Mar — 318-22

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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