The Drug-Induced Respiratory Disease Website

Anticoagulants, oral (vitamin K antagonists-VKA)

Hemothorax - Serosanguineous pleural effusion

Azfar Ali H, Lippmann M, Mundathaje U, Khaleeq G

Spontaneous hemothorax: a comprehensive review.

Chest 2008 Nov;134;1056-1065 — 2008 Nov — 1056-1065

Abaskaron M, Peterson G, Huang TY

Anterior mediastinal haematoma and left haemothorax on well-controlled oral anticoagulant therapy.

Postgraduate medical journal 1983 Feb;59;95-7 — 1983 Feb — 95-7

Simon HB, Daggett WM, DeSanctis RW

Hemothorax as a complication of anticoagulant therapy in the presence of pulmonary infarction.

JAMA 1969 Jun 09;208;1830-4 — 1969 Jun 09 — 1830-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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