The Drug-Induced Respiratory Disease Website

Anticoagulants, direct oral (anti-thrombin, -IIa, -Xa) - NOAC

Epistaxis

Review at PMID 30454778. Emergent management at PMID 27836741

Gökdo?an O, Akyildiz I, Sayin BY, Okutucu S, Tanalp AC, Arslan N

The Rate of Epistaxis Incidence in New-Generation Anticoagulants and Perioperative Approach in Otorhinolaryngological Practices.

The Journal of craniofacial surgery 2017 Mar;28;e178-e182 — 2017 Mar — e178-e182

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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