The Drug-Induced Respiratory Disease Website

Osimertinib

QTc prolongation

May expose to ventricular arrhythmia and deah. See also PMID 23541006, 26706796, 29473523, 29458991. Continuously uptated list of drugs available at CredibleMeds website: http://www.qtdrugs.org

Publications

Ikebe S, Amiya R, Minami S, Ihara S, Higuchi Y, Komuta K

Osimertinib-induced cardiac failure with QT prolongation and torsade de pointes in a patient with advanced pulmonary adenocarcinoma.

International cancer conference journal 2021 Jan;10;68-71 — 2021 Jan — 68-71

Schiefer M, Hendriks LEL, Dinh T, Lalji U, Dingemans AC

Current perspective: Osimertinib-induced QT prolongation: new drugs with new side-effects need careful patient monitoring.

European journal of cancer (Oxford, England : 1990) 2018 03;91;92-98 — 2018 03 — 92-98

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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