The Drug-Induced Respiratory Disease Website

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.f Tachycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

II. Myocardial dysfunction - Heart failure

II.e Acute respiratory or cardiopulmonary failure

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

III. Myocardial ischemia - Coronary artery disease

III.g ST segment changes

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

X. Pulmonary edema

X.c Interstitial pulmonary edema

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.y Cytokine release syndrome

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.n Respiratory arrest - Apnea

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.b Eosinophilic myocarditis

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.i Torsades de pointe

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.e Path: Lysosomal storage cardiomyopathy/cardiotoxicity

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e Bradycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.i Torsades de pointe

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.m Subclinical pulmonary infiltrates/ILD

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.u Transient pulmonary opacities/infiltrates (TAPO)

XXXIX. Rechallenge

XXXIX.a Rechallenge can lead to near-fatal or fatal relapse of AE/ILD

XXXIX. Rechallenge

XXXIX.e Rechallenge may not lead to relapse of the AE/ILD

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.f Capillary leak syndrome (CLS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.i Guillain-Barré (or GB-like) syndrome (w/wo ARF)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.ac Antisynthetase antibodies (ASA) - ASA syndrome

XXXVIII. Miscellaneous - Varia

XXXVIII.k Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)