Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

Trastuzumab

I - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
I.g

QTc prolongation

II - Myocardial dysfunction - Heart failure

II.a

Left ventricular dysfunction/failure

VI - Cardiomyopathy

VI.a

Cardiomyopathy (acute, subacute, chronic)

VII - Cardiotoxicity

VII.a

‘Cardiotoxicity’

X - Pulmonary edema

X.f

Capillary leak syndrome (CLS)

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.j

Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIX - Small airway involvement

XXIX.a

Bronchospasm - Wheezing - Asthma

XXXVI - Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f

Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)
XXXVI.i

Guillain-Barré (or GB-like) syndrome (w/wo ARF)
XXXVI.ac

Antisynthetase antibodies (ASA) - ASA syndrome

XXXVIII - Miscellaneous - Varia

XXXVIII.k

Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)