The Drug-Induced Respiratory Disease Website

CAR T-cell therapy

Acute respiratory or cardiopulmonary failure

With or without demonstrable pulmonary opacities. Mechanical ventilation is often required. See also under Ia, IIa, IIb, IXa, IXd, IXj

Goldman A, Maor E, Bomze D, Liu JE, Herrmann J, Fein J, Steingart RM, Mahmood SS, Schaffer WL, Perales MA, Shouval R

Adverse Cardiovascular and Pulmonary Events Associated With Chimeric Antigen Receptor T-Cell Therapy.

Journal of the American College of Cardiology 2021 11 02;78;1800-1813 — 2021 11 02 — 1800-1813

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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