Philippe Camus, M.D.

Dijon, France

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The Drug-Induced Respiratory Disease Website

Osimertinib

I - Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
I.g

QTc prolongation

II - Myocardial dysfunction - Heart failure

II.c

Heart failure (biventricular, congestive)

VII - Cardiotoxicity

VII.a

‘Cardiotoxicity’

XVI - Hemorrhage - Bleeding - Hematoma(s)

XVI.e

Alveolar hemorrhage (AH), diffuse AH (DAH)

XXIV - Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a

Pneumonitis (ILD)
XXIV.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)
XXIV.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
XXIV.m

Subclinical pulmonary infiltrates/ILD
XXIV.u

Transient pulmonary opacities/infiltrates (TAPO)

XXXIX - Rechallenge

XXXIX.a

Rechallenge can lead to near-fatal or fatal relapse of AE/ILD
XXXIX.e

Rechallenge may not lead to relapse of the AE/ILD