The Drug-Induced Respiratory Disease Website

Proton pump inhibitors

Respiratory tract infection incl. pneumonia

Not all studies will demonstrate an increase in risk (PMID 29601438)

Maret-Ouda J, Panula J, Santoni G, Xie S, Lagergren J

Proton pump inhibitor use and risk of pneumonia: a self-controlled case series study.

Journal of gastroenterology 2023 Aug;58;734-740 — 2023 Aug — 734-740

Safe M, Chan WH, Leach ST, Sutton L, Lui K, Krishnan U

Widespread use of gastric acid inhibitors in infants: Are they needed? Are they safe?

World journal of gastrointestinal pharmacology and therapeutics 2016 Nov 06;7;531-539 — 2016 Nov 06 — 531-539

Laheij RJ, Sturkenboom MC, Hassing RJ, Dieleman J, Stricker BH, Jansen JB

Risk of community-acquired pneumonia and use of gastric acid-suppressive drugs.

JAMA 2004 Oct 27;292;1955-60 — 2004 Oct 27 — 1955-60

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.