The Drug-Induced Respiratory Disease Website

Rifampicin

Multiple organ dysfunction/failure (MODS/MOF)

Publications

Brockhaus L, Schmid Y, Rast AC, Rätz Bravo AE, Hofmeier KS, Leuppi-Taegtmeyer AB

Hypersensitivity reaction with multi-organ failure following re-exposure to rifampicin: case report and review of the literature including WHO spontaneous safety reports.

BMC pharmacology & toxicology 2019 Feb 12;20;9 — 2019 Feb 12 — 9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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