The Drug-Induced Respiratory Disease Website

Benzonatate

Cardiac- cardiorespiratory/pulmonary arrest

Jin C, Zahid E, Sherazi A, Majumder MR, Bedi P

Cardiac Arrest Due to Benzonatate Overdose.

The American journal of case reports 2019 May 03;20;640-642 — 2019 May 03 — 640-642

Yoshioka I, Surmaitis R, Katz KD

A 17-Year-Old Girl With Cough--Pulseless After Drug Overdose. Sodium benzonatate overdose.

Pediatric emergency care 2016 Mar;32;197-9 — 2016 Mar — 197-9

Cohen V, Jellinek SP, Stansfield L, Truong H, Baseluos C, Marshall JP

Cardiac arrest with residual blindness after overdose of Tessalon® (benzonatate) perles.

The Journal of emergency medicine 2011 Aug;41;166-71 — 2011 Aug — 166-71

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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