The Drug-Induced Respiratory Disease Website

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.e Bradycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

X. Pulmonary edema

X.d Fluid retention

XIII. Thrombosis - Embolism

XIII.f Fat/oil embolism - The FES embolism syndrome

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.j Organizing pneumonia (OP/BOOP) pattern (an area or areas of consolidation on imaging)

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXXIII. Histopathology (for pulmonary pathology see in ‘Pneumotox’ (a free companion App)

XXXIII.o Path: Lipid/fat embolism

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVIII. Miscellaneous - Varia

XXXVIII.a Upper airway obstruction other than angioedema or hematoma

XXXVIII. Miscellaneous - Varia

XXXVIII.k Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.e Acute respiratory or cardiopulmonary failure

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

XXII. Acute respiratory/cardiorespiratory failure

XXII.e Respiratory failure from ventilatory depression (of neuromuscular cause or causes)

XXII. Acute respiratory/cardiorespiratory failure

XXII.f Rigid chest syndrome - Chest wall rigidity - Stiff/wooden chest

XXVIII. Large airway involvement

XXVIII.d Vocal cord dysfunction, adduction, closure

XXVIII. Large airway involvement

XXVIII.f Laryngospasm (a.k.a. laryngismus)

XXXV. Disordered breathing during sleep

XXXV.b Disordered breathing pattern - Cheynes-Stokes respiration

XXXVIII. Miscellaneous - Varia

XXXVIII.n Hiccup

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

XXII. Acute respiratory/cardiorespiratory failure

XXII.a Respiratory distress or failure, not otherwise specified

XXVIII. Large airway involvement

XXVIII.d Vocal cord dysfunction, adduction, closure

XXVIII. Large airway involvement

XXVIII.f Laryngospasm (a.k.a. laryngismus)

XXXVIII. Miscellaneous - Varia

XXXVIII.a Upper airway obstruction other than angioedema or hematoma

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.k Multiple organ dysfunction/failure (MODS/MOF)

XXXVIII. Miscellaneous - Varia

XXXVIII.k Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

XXII. Acute respiratory/cardiorespiratory failure

XXII.f Rigid chest syndrome - Chest wall rigidity - Stiff/wooden chest

XXVIII. Large airway involvement

XXVIII.j Trismus (lockjaw)

XXXVIII. Miscellaneous - Varia

XXXVIII.d Death following exposure or poisoning

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXXVIII. Miscellaneous - Varia

XXXVIII.m Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.f Tachycardia

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

II. Myocardial dysfunction - Heart failure

II.c Heart failure (biventricular, congestive)

II. Myocardial dysfunction - Heart failure

II.d Cardiovascular collapse - Cardiogenic shock - Hypotension

II. Myocardial dysfunction - Heart failure

II.e Acute respiratory or cardiopulmonary failure

III. Myocardial ischemia - Coronary artery disease

III.c Coronary vasospasm - Vasospastic angina

III. Myocardial ischemia - Coronary artery disease

III.g ST segment changes

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

VII. Cardiotoxicity

VII.a ‘Cardiotoxicity’

X. Pulmonary edema

X.b Pulmonary edema, noncardiogenic (NCPE)

X. Pulmonary edema

X.c Interstitial pulmonary edema

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XIV. Pleural involvement

XIV.a Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.i Hemoptysis

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.k Pulmonary infiltrates

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.y Cytokine release syndrome

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.n Respiratory arrest - Apnea

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.g QTc prolongation

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.n Respiratory arrest - Apnea

IV. Heart block (bundle branch-, AV-block)

IV.a Heart block (bundle branch- or AV-)

V. Myocarditis

V.b Eosinophilic myocarditis

VI. Cardiomyopathy

VI.a Cardiomyopathy (acute, subacute, chronic)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.a Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

I. Cardiac arrhythmia(s)/dysrhythmia(s) (AF, VT, VF, TdP) - QTc prolongation)

I.l Cardiac- cardiorespiratory/pulmonary arrest

II. Myocardial dysfunction - Heart failure

II.a Left ventricular dysfunction/failure

III. Myocardial ischemia - Coronary artery disease

III.a Coronary artery disease (acute) - Myocardial ischemia/infarction

V. Myocarditis

V.a Myocarditis (can be fulminate/fulminant)

V. Myocarditis

V.b Eosinophilic myocarditis

V. Myocarditis

V.f Myopericarditis

V. Myocarditis

V.h Relapse of previously diagnosed myocarditis

VI. Cardiomyopathy

VI.c Takotsubo (stress) cardiomyopathy

X. Pulmonary edema

X.a Pulmonary edema, cardiogenic

XI. Pulmonary vasculopathies

XI.a Pulmonary arterial hypertension

XI. Pulmonary vasculopathies

XI.j Pulmonary infarction

XII. Pericardial involvement

XII.a Pericarditis

XII. Pericardial involvement

XII.b Pericardial effusion (w/wo tamponade)

XII. Pericardial involvement

XII.e Constrictive pericarditis - Pericardial thickening

XIII. Thrombosis - Embolism

XIII.a Pulmonary embolism - Venous thrombosis/thrombo-embolism

XV. Chest pain

XV.a Chest pain (acute or subacute), lone or prominent

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.e Alveolar hemorrhage (AH), diffuse AH (DAH)

XVI. Hemorrhage - Bleeding - Hematoma(s)

XVI.h Coagulopathy

XX. Vasculitis

XX.c Vascultis (pulmonary, extrathoracic or systemic) - ANCA status unknown or negative

XX. Vasculitis

XX.d Vasculitis, pulmonary (w/wo AH), extrathoracic, or systemic: ANCA-positive

XXII. Acute respiratory/cardiorespiratory failure

XXII.b Acute lung injury - ARDS

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.a Pneumonitis (ILD)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.b Pneumonitis (ILD), acute and/or severe (may cause ARDS)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.i Progression, acceleration or exacerbation of preexisting ILD/fibrosis

XXIV. Interstitial lung disease - Pulmonary infiltrates - Pulmonary fibrosis

XXIV.v Radiation recall pneumonitis

XXIX. Small airway involvement

XXIX.a Bronchospasm - Wheezing - Asthma

XXIX. Small airway involvement

XXIX.h Exacerbation or deterioration of preexisting asthma

XXX. Imaging features

XXX.l Imaging: Ground-glass opacities / GGO shadowing

XXX. Imaging features

XXX.p Imaging: Asymmetrical, predominantly unilateral involvement

XXX. Imaging features

XXX.s Imaging: A mosaic pattern of attenuation

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.b Lupus - Lupus syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.f Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.i Guillain-Barré (or GB-like) syndrome (w/wo ARF)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.j Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.n A flare of preexisting immune-mediated systemic/rheumatic disease

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.x Anti Jo1 syndrome

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.z Protracted, prolonged anaphylaxis

XXXVI. Autoimmune syndromes - Systemic reactions or conditions

XXXVI.ae Polyarteritis nodosa-like condition

XXXVIII. Miscellaneous - Varia

XXXVIII.c Antiphospholipid antibodies w/wo the APL syndrome

XXXVIII. Miscellaneous - Varia

XXXVIII.q Myopathy-Myositis-Polymyositis