The Drug-Induced Respiratory Disease Website

Amantadine

Cardiac- cardiorespiratory/pulmonary arrest

Bakhati B, Sibi VM, Mekala AP, Ronen JA, Mungara SS

Amantadine-Induced Cardiac Arrest in a Patient With COVID-19.

Cureus 2022 Jan;14;e21345 — 2022 Jan — e21345

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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