The Drug-Induced Respiratory Disease Website

Nitrofurantoin

A ‘tracheobronchitis’ clinical pattern

Bayer WL, Dawson RB, Kotin E

Allergic tracheobronchitis due to nitrofurantoin sensitivity. Report of a case.

Diseases of the chest 1965 Oct;48;429-30 — 1965 Oct — 429-30

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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