The Drug-Induced Respiratory Disease Website

Rivaroxaban

Hemothorax - Serosanguineous pleural effusion

Yan DT, Heng RGK, Ng HJ

Massive Spontaneous Haemothorax after Rivaroxaban Therapy for Acute Pulmonary Embolism.

European journal of case reports in internal medicine 2019;6;001236 — 2019 — 001236

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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