The Drug-Induced Respiratory Disease Website

Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

Ramanathan K, Mohanty B, Tang S, MacLaren G

Extracorporeal therapy for amlodipine poisoning.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 2019 Sep 24;; — 2019 Sep 24

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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