The Drug-Induced Respiratory Disease Website

Nitrofurantoin

Lymphadenopathy (intrathoracic)

Can be hilar and/or mediastinal. Typically detected on imaging. Pathology may reveal granulomatous or reactive changes

Karmali R, Stawitzky K, Srisethnil I, Simpson K

A rare case of nitrofurantoin-induced acute lung injury.

Clinical case reports 2020 Oct;8;2029-2033 — 2020 Oct — 2029-2033

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.