The Drug-Induced Respiratory Disease Website

Alteplase (rTPA)

Epistaxis

Review at PMID 30454778. Emergent management at PMID 27836741

Khandelwal P, Martínez-Pías E, Bach I, Prakash T, Hillen ME, Martínez-Galdámez M, Arenillas JF

Severe Epistaxis after Tissue Plasminogen Activator administration for Acute Ischemic Stroke in SARS-COV-2 Infection.

Brain circulation 2021 Apr-Jun;7;135-138 — 2021 Apr-Jun — 135-138

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.