The Drug-Induced Respiratory Disease Website

Trimethoprim sulfamethoxazole (TMP-SMX)

Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

Rubin J, Chiu ML, Mino-Kenudson M, Sharma A, Witkin AS, Moschovis PP, Vogel Y, Shelton K, Crowley J, Raz Y

ARDS With Pneumothorax in a Young Adult.

Chest 2022 Feb;161;e111-e116 — 2022 Feb — e111-e116

Nasim F, Paul JA, Boland-Froemming J, Wylam ME

Sulfa-induced acute eosinophilic pneumonia.

Respiratory medicine case reports 2021;34;101496 — 2021 — 101496

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.