The Drug-Induced Respiratory Disease Website

Sertraline

Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

Izhakian S, Rosengarten D, Pertzov B, Grubstein A, Heching M, Fridel L, Kramer MR

Sertraline-Associated Interstitial Lung Disease: A case series and Literature Review.

Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG 2021;38;e2021027 — 2021 — e2021027

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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