The Drug-Induced Respiratory Disease Website

Bevacizumab

Esophageal pleural fistula

Wang T, Thakur A, Chen B

Bevacizumab-induced esophageal pleural fistula during maintenance therapy without radiation in lung cancer.

BMC pulmonary medicine 2021 Nov 25;21;384 — 2021 Nov 25 — 384

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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