The Drug-Induced Respiratory Disease Website

Naloxone

Acute respiratory failure (e.g. from ARDS, ILD, PIE, OP, pulmonary edema or bronchospasm) requiring ECMO

Kummer RL, Kempainen RR, Olives TD, Leatherman JW, Prekker ME

Naloxone-associated pulmonary edema following recreational opioid overdose: A case series.

The American journal of emergency medicine 2021 Dec 17;53;41-43 — 2021 Dec 17 — 41-43

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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